This report summarizes a national conference that took place in Arlington, VA, on March 20-21, 2003. The conference was jointly sponsored by the Department of Health and Human Services Administration for Children and Families (ACF) and Substance Abuse and Mental Health Services Administration (SAMHSA). This conference brought together substance abuse treatment agency directors and Temporary Assistance for Needy Families (TANF) administrators from forty States, the District of Columbia, and the Virgin Islands. The conference provided a forum for these policymakers and administrators to share information about their experience and concerns, and their promising strategies used in strengthening the collaboration and partnership of TANF and substance abuse treatment directors.